The papillary dermis is approximately 300-400 μm deep. This depth is variable and depends upon such factors as age and anatomical location. Typically, the superficial portion of the papillary dermis is arranged into ridge-like structures, the dermal papillae, which contain microvascular and neural components that sustain the epidermis (Cormack, 1987). Dermal papillae greatly extend the surface area for epithelial-mesenchymal interactions and delivery of soluble molecules to the epidermis. A vascular plexus, the rete subpapillare, demarcates the lower limit of the papillary dermis (Figs 1, 2). The reticular layer of the dermis extends from this superficial vascular plexus to a deeper vascular plexus, the rete cutaneum, which serves as the boundary between the dermis and hypodermis. Hair follicles and their associated dermal cells extend into and often through the reticular dermis to terminate in the hypodermis, a tissue rich in adipocytes.